Endocrine Abstracts

: Non-thyroidal-illness syndrome (NTIS) is present in chronic renal failure and considered an adaptive mechanism. However oxidative stress is linked to NTIS in a vicious circle, due to deiodinases alteration and negative effect on antioxidant levels or activity. One key antioxidant, protective toward ROS-mediated tissue damage, is extracellular superoxide-dismutase (ec-SOD), present in extracellular matrix and with a role in mediating nitric oxide-induced signaling. ec-SOD is ...